(Syn. : CVFm)
CVFm (Cobra Venom Factor) | Product ID | L8117-100UG |
| Name | CVFm (Cobra Venom Factor) |
| Molecular formula | Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits |
| Description |
It is a non-toxic, complement-activating component of cobra venom. Purified from Naja melanoleuca venom, a non-CITES Naja species. Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits with molecular masses respectively of about 70, 50, and 30 kDa, the two large subunits being glycosylated. From Naja melanoleuca venom. |
| Biological activity | It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
Field of use: It is used for immuno-suppression, decomplementing blood in vivo & in vitro, its dosage for mice is about 1µg per gram of body weight.
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Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 125.00 | ||
| 5 Unité(s) | 500.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8117-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8117-100UG | Molecular weight | ~ 150 kDa |
| Product name | CVFm (Cobra Venom Factor) | Physical form | Lyophilized |
| CAS No. | 308067-24-5 | Melting point | |
| RTECS | Solubility | In acetonitrile solution (51%AcN / 49% water). In DMSO 2.5 %. Not in water, not in PBS. | |
| UNIPROT | Q91132 | Optical Activity | |
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| Purity | > 95% (HPLC) | ||
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| Storage & Reconstitution Recommandations |
Shipped at ambient temperature under lyophilized powder. In solution, store at -20°C (-4°F). Do not freeze-thaw. Aliquot sample if required and store at -80°C (-112°F).
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| Savety Recommandations |
For research use only — not intended for food, diagnostic or therapeutic use
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Bibliographic References
| Product code | L8117-100UG |
| Product name | CVFm (Cobra Venom Factor) |
- Toxicon. 2005 Sep 15;46(4):394-403. "Naja melanoleuca cobra venom contains two forms of complement-depleting factor (CVF)". Osipov AV, Mordvintsev DY, Starkov VG, Galebskaya LV, Ryumina EV, Bel'tyukov PP, Kozlov LV, Romanov SV, Doljansky Y, Tsetlin VI, Utkin YN.
Links
| Product code | L8117-100UG |
| Product name | CVFm (Cobra Venom Factor) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
