a neuronal nicotinic AChR antagonist. Potent ganglioblocker. Hypotensive. Good penetration of biological membranes. Rigid bicyclic analog of Pempidine. Non-quaternary analog of Quirestine.

For comparative information see the attached 2 tables.
Cell permeant central nicotinic acetylcholine receptor blocker without action on skeleton muscle innervation. Quinuclidine analog of Pempidine, non-quaternary analog of Quirestine. Hypotensive, selectively blocks autonomic ganglia, the adrenal medulla, carotid glomerules.

Three-fold more active than Pempidine, wide therapeutic range [1]. Slows down neuronal pre- and post ganglionar transmission: dilates peripheral vessels and bronchi, arterial pressure and pressor reaction drop. Suppresses gland secretion. Sedative.

Good penetration of biological membranes.

Blocks superior cervical sympathetic ganglion (electrical stimulation of cats nictiating membrane): ED₅₀ = 17 �g/kg , Pempidine 54 �g/kg.

Blocks autonomic ganglion ( vagus electrical stimulation): depressor reaction suppression - 50 �g /kg 40%, 500 �g/kg 100%. After 100% nicotinic blockade with 500 �g /kg, cardiac system still reacts to muscarinic action of ACh (i.v.).

store at room temperature. Solution for use: dissolve in water: 10-³M (2 mg in 8.06 ml), stable for 1-2 days at 20°C.

do not swallow or inhale; avoid eye and skin contact.