SOLASODINE
Product ID L6096 
Name SOLASODINE 
Molecular formula C27H43O2N
Description

It is a cytotoxic substance for cancer cells.

It is active against anaphylactic, insulin shock, and shocks resulting from burns.


Steroid alkaloid , from plants of the Solanaceae family
Biological activity

Solasodine presents several glucocorticoid-like effects: active against shocks of various origin, hypocholesterolaemic and antiatherosclerotic.

It enhances the glucocorticoids secretion by adrenal glands. In prolonged use, it causes atrophy of the adrenal gland cortex. It possesses also an embryotoxic activity and cumulative effects.

It also presents a juvenomimetic activity on insect larvas.

5 mg/kg cause a short-acting cerebral stimulation and improve the conditioned reflex activity. It presents the opposite effects with repeated administration.

Solasodine glycosides present a selective cytotoxicity for cancer cells.

Recommended doses: 0.1 - 5.0 mg/kg (p.o., i.v.)

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 104.00

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100 mg 416.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6096 : unit price : free of charge
 Chemical and Physical Properties
Product code L6096  Molecular weight 413.64 g/mol
Product name SOLASODINE  Physical form
CAS No. 126-17-0 Melting point 200-202 °C
RTECS WF1300000 Solubility In chloroform
Not well in acetone, methanol, ethanol
UNIPROT Optical Activity [alpha]D - 97° (methanol)
PubChem SID    
PubChem CID 5250    
Purity > 97%    
Toxicity(LD50) ORL-MUS LD50: 27.5 mg/kg    
Chemical Name    
Storage & Reconstitution
Recommandations

Store at +4°C, in dark place;

Solution for experiment: 10-5 - 10-2 g/ml


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6096 
Product name SOLASODINE 

- Cham et al., "Solasodine glycosides. Selective toxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180." Cancer Letters (1990). 55(3):221-225
- Dixit et al., "Hypocholesterolaemic and antiatherosclerotic effects of solasodine." Phytotherapy Research (1992). 6(5):270-273
- Sabita Raja et al., "Juvenomimetic effects of Solasodine on Chilo partellus." Current Science (1987). 56(17):913-915
- Daroczy et al., "On the glucorticoid-like effects of Solanum alkaloids." Acta Biochim. et Biophys. Acad. Sci. Hung. (1971). 6(4):327-331
 Links
Product code L6096 
Product name SOLASODINE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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