It is a psychotomimetic agent on dogs and cats and an acetylcholinesterase inhibitor.

Psychotomimetic effects: (unpublished results) dogs are specially sensitive to the psychotomimetic effects of Peganole.
- 0.5 mg/kg (s.c.) on dogs (5-10 mg/kg on rats): disruption of conditioned reflex.
- 1.0 mg/kg (i.v.): burst of motor activity and aggressiveness: usually, gentle dogs start growling, barking and biting various objects with fury during 15 to 20 minutes. After this period, dogs are depressed during 4 to 6 hours.
- 3-5 mg/kg (i.v.) inhibit the synchronization of the main rhythm in the cortex and the reticular formation (activation reaction).
- 31 mg/kg and 62 mg/kg (respectively 0.25 and half DL₅₀) enhance respectively 2 and 2.5 times the length of sleep caused by chloral hydrate, although Peganole does not possesses any soporific effect by itself.
Cholinergic effects: The main cholinergic effects of Peganole on mice (i.p., i.v. and s.c.) are as follow:
- speeds up the breath rhythm;
- causes tremor and clonic cramps;
- enhances salivation and blood pressure.
Peganole increases the effects of the cholinergic transmission in the CNS and at the neuromuscular junction. At 15, 30 and 50 mg/kg (i.p.), it increases respectively 1.5, 2 and 2.5 times the effects of Arecoline on tremor and 1.0, 1.8 and 3 times the effects of Nicotine. It inhibits both cholinesterases and monoamine oxydases.

Store at +4 °C, in dark place.

For research use only — not intended for food, diagnostic or therapeutic use