L8501-100UG - CONOTOXIN MVII A (Omega-)
(Syn. : Ziconotide, SNX-111, omega-CgTx MVIIvA)
(Syn. : Ziconotide, SNX-111, omega-CgTx MVIIvA)
CONOTOXIN MVII A (Omega-) | Product ID | L8501-100UG |
| Name | CONOTOXIN MVII A (Omega-) |
| Molecular formula | C102H172N36O32S7 |
| Description |
It is a N-type Ca2+ channel blocker. 25-amino acid peptide with 3 disulfide bridges , synthetic, originally from Conus magus molluscan venom. |
| Biological activity | ω-CgTx MVIIvA blocks Cav2.2/CACNA1B calcium channels (IC50=180 nM). When injected in mammals, it induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion. ω-Conotoxin MVIIvA (from Conus magus) and ω-Conotoxin GVI A (from Conus geographus) are both neuronal Cav2 channel blockers and appear to compete for the same sites in mammalian brain, but they seem to present some differences in their receptor binding characteristics; in particular the high affinity binding of MVII A has narrower specificity in amphibian brain. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 90.00 | ||
| 5 Unité(s) | 360.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8501-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8501-100UG | Molecular weight | 2,639.2 Da |
| Product name | CONOTOXIN MVII A (Omega-) | Physical form | |
| CAS No. | 107452-89-1 | Melting point | |
| RTECS | Solubility | Well in water and saline | |
| UNIPROT | P05484 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 16135415 | ||
| Purity | ~ 85 % (HPLC) | ||
| Toxicity(LD50) | |||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze dried state. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8501-100UG |
| Product name | CONOTOXIN MVII A (Omega-) |
- Olivera et al., "Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using Omega-conotoxin from Conus magus venom." Biochemistry. (1987) 26:2086-2090
Links
| Product code | L8501-100UG |
| Product name | CONOTOXIN MVII A (Omega-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
