NAPELLINE
Product ID L6215 
Name NAPELLINE 
Molecular formula C22H33NO3
Description

it is a potent antiarrhythmic of class I with weak hypotensive and N-cholinoblocking effects.


Diterpenoid alkaloid , from plants of the Aconitum genus, Ranunculaceae
Biological activity

Napelline has a stronger antiarrhythmic activity than Quinidine or Procaïnamide.
10-4 - 10-5 M block inward Na+ currents.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 106.00

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100 mg 424.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6215 : unit price : free of charge
 Chemical and Physical Properties
Product code L6215  Molecular weight 359.50 g/mol
Product name NAPELLINE  Physical form Yellowish crystal powder
CAS No. 5008-52-6 Melting point 162-164 °C
RTECS GZ4950000 Solubility Well in chloroform
Moderately in acetone and methanol
Not well in water
UNIPROT Optical Activity
PubChem SID    
PubChem CID 90473812    
Purity > 91%    
Toxicity(LD50) IVN-MUS LD50: 87.5 mg/kg
IPR-MUS LD50: 280 mg/kg
   
Chemical Name (2R,4S,5R,7R,10R,13R,16S,17R)-11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol    
Storage & Reconstitution
Recommandations

Stable in dry state;
Store at 4°C, in dark place.
Solutions for experiments
- in vitro
: 10-6 to 10-5 M;
- doses for one experiment in vivo: 10-20 mg/kg


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6215 
Product name NAPELLINE 

- "The Alkaloids" R.H.F. Manske Ed. (Academic Press Inc., New-York) (1955). 4:291
- Okamoto et al., Chem. and Pharm. Bull. (1965) (Japan). 13:1270
- Djahangirov et al., "Pharmacology of the alkaloids Napelline and Heteratisine" Rpts. Acad. Sciences Uzb. (1977) (Russian). 3:50-51
 Links
Product code L6215 
Product name NAPELLINE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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