As a neurotoxic, it opens the TTX-sensitive Na⁺ channels in the heart and other tissues and induces arrhythmia.

The activity of Mesaconitine, which is a chemical analog of Aconitine, on TTX sensitive Na⁺ channels in the heart and other tissues is stronger than that of Aconitine. The duration of its neurotoxic effect is shorter.
It possesses an hypotensive activity. In rats under anaesthesia, 50 μg/kg (i.v.) temporarily decrease blood pressure. The hypotensive action is not inhibited by an adrenergic b-blocker but abolished with muscarinic blocker. It may be partially mediated by a muscarinic mechanism.

Store at +4°C, in dark place.
Solutions for use:
- in vitro: 10^-6-10^-8 M;
- for experiments on antiarrhythmia (rat): 4 to 10 μg/kg

For research use only — not intended for food, diagnostic or therapeutic use
Extremely toxic (class A): avoid penetration in the eyes, mouth and nose;
Use a mask, goggles and rubber gloves.