MCD PEPTIDE
Product ID L8402-5MG 
Name MCD PEPTIDE 
Molecular formula C110H192N40O24S4
Description

It is a blocker of voltage-sensitive K+ channels with potent convulsant activity.


22-amino acid peptide with a strongly basic character and 2 disulfide bridges , from Apis mellifera bee venom.
Biological activity

Mast cell degranulating activity: it causes histamine release with half-maximal effects in rat peritoneal mast cell preparations at concentrations of 2 X 10-8 M.
MCD Peptide binds with high affinity (Kd = 150 pM) to rat synaptic membranes. This binding induces the inhibition of a voltage sensitive K+ current and produces hippocampal responses (long term potentiation, Theta rhythm and epileptiform seizures).

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 Unité(s) 118.00

add to cart add to cart

5 Unité(s) 472.00

add to cart add to cart

For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L8402-5MG : unit price : free of charge
 Chemical and Physical Properties
Product code L8402-5MG  Molecular weight 2587.22 Da
Product name MCD PEPTIDE  Physical form
CAS No. 32908-73-9 Melting point
RTECS Solubility Well in water and saline
UNIPROT P01499 Optical Activity
PubChem SID    
PubChem CID 16132290    
Purity    
Toxicity(LD50) IPR-MUS LD50: 125 mg/kg
ICE-MUS LD50: 6.8 µg/kg
   
Chemical Name    
Storage & Reconstitution
Recommandations

Reconstitution recommendations: 125 μl of distilled water added to a 50 μg vial gives a 100 μM MCD Peptide solution.
Store preferably at -20 °C. The solution can be freezed and thawed.


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L8402-5MG 
Product name MCD PEPTIDE 

- Taylor et al., J. Biol. Chem. (1984). 259:13957-13967
- Bidard et al. Brain Res. (1987). 418:235-244
- Cherubini et al., Nature (1987) 328:70-73
 Links
Product code L8402-5MG 
Product name MCD PEPTIDE 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
UNIPROT
click to zoom

LOGIN
Welcome, click here to   Login !




Adress:
ZA Les Auréats, 845 Avenue Pierre Brossolette
26800 PORTES lès VALENCE - FRANCE

Phone:
+33 475 419 191

Email:
latoxan[@]latoxan.com

Web link:
www.latoxan.com