LYCACONITINE Perchlorate
Product ID L6221 
Name LYCACONITINE Perchlorate 
Molecular formula C36H48N2O10.HClO4
Description

It is a ganglion blocking agent as it is a nicotinic receptor antagonist at the neuromuscular junction.
It is also a potent medium-acting muscle relaxant and hypotensive belonging to the family of non depolarizing myorelaxant. It is an antagonist of Proserine, Galanthamine.


C19-norditerpenoid alkaloid , purified from plants of the Aconitum genus, Ranunculacae
Biological activity

It has a good penetration of the blood-tissue barrier. It acts on nicotinic cholinoreceptors of the Peripheral and Central Nervous Systems, whatever the way of administering in vivo.
On cat under anaesthesia, 1.5 mg/kg (i.v.) or 30 mg/kg (p.o.) block the activity of N-cholinoreceptors at the neuromuscular junction. 10-5 g/ml block the neuromuscular transmission on the rat diaphragm preparation.
0.5-2 mg/kg (i.v.) on cat under anaesthesia, cause hypotension due to the blockade of the transmission of nervous impulses in sympathetic and orthosympathetic ganglia.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
20 mg 250.00

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100 mg 1 000.00

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 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L6221 : unit price : free of charge
 Chemical and Physical Properties
Product code L6221  Molecular weight 769.23 g/mol
Product name LYCACONITINE Perchlorate  Physical form Cream-white crystal
CAS No. 321938-55-0 Melting point 184-186 °C (ethanol; forming foam)
Softens at 170°C.
RTECS Solubility Moderately in water and methanol
Not well in ethanol
UNIPROT Optical Activity
PubChem SID    
PubChem CID 51346125    
Purity    
Toxicity(LD50) ORL-MUS LD50 : 31 mg/kg
IVN-MUS LD50: 2.6 mg/kg
IPR-MUS LD50: 12.5 mg/kg
   
Chemical Name [(1S,2R,3R,4S,5R,6S,8R,9S,13S,16S,17R,18S)-11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl]methyl 2-(2,5-dioxopyrrolidin-1-yl)benzoate;perchloric acid    
Storage & Reconstitution
Recommandations

Stable in dry state, store at + 4°C, in dark place.
Solution for experiments in vitro: 10-5 - 10-7 M.
Doses for experiments in vivo on cats and dogs: 1-3 mg/kg (i.v.) or 20-30 mg/kg (p.o.).


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L6221 
Product name LYCACONITINE Perchlorate 

- Pelletier et al., J. Am. Chem. Soc.(1981) 103:6536-6538
- Shamma et al., J. Nat. Prod. (1979). 42:615-623
- Djahangirov, "About the pharmacology of the alkaloid Lycaconitine." Problems of Pharmacology and Pharmacy, Tashkent (1976) (Russian). 4: 21-22
 Links
Product code L6221 
Product name LYCACONITINE Perchlorate 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
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