L8112-1MG - ELAPITOXIN-Ls2a (alpha-)
(Syn. : Ls III)
(Syn. : Ls III)
ELAPITOXIN-Ls2a (alpha-) | Product ID | L8112-1MG |
| Name | ELAPITOXIN-Ls2a (alpha-) |
| Molecular formula | |
| Description |
It is an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b 66-amino acid peptide with 5 disulfide bridges , from Laticauda semifasciata snake venom |
| Biological activity | It is a nicotinic receptor antagonist, with a reversible binding to the receptor (its affinity is 1/40th that of Erabutoxin b). |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 192.00 | ||
| 5 Unité(s) | 768.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8112-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8112-1MG | Molecular weight | 7,229 Da |
| Product name | ELAPITOXIN-Ls2a (alpha-) | Physical form | |
| CAS No. | 75433-28-2 | Melting point | |
| RTECS | Solubility | In water and saline | |
| UNIPROT | P01379 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | |||
| Purity | > 90 %. Salt-free, freeze-dried preparation Homogeneous (CM-cellulose & gel-chromatography) |
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| Toxicity(LD50) | IMU-MUS LD50: 0.85 mg/kg | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state. Keep in dark and cold place. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8112-1MG |
| Product name | ELAPITOXIN-Ls2a (alpha-) |
- Tamiya et al., "Studies on sea-snake venoms: crystallization of Erabutoxins a and b from Laticauda semifasciata venom." Biochem. J. (1966). 99:624-630
- Ishikawa et al., "Structures of snake toxins and their affinity to the acetylcholine receptor of fish electric organ." Toxicon (1977). 15:477-488
- Chiappinelli et al., "The effects of a- and b- neurotoxins from the venoms of various snakes on transmission in autonomic ganglia." Brain Res. (1981). 211:107-126
- Endo et al. "Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms." Pharmac. Ther. (1987). 34:403-451
Links
| Product code | L8112-1MG |
| Product name | ELAPITOXIN-Ls2a (alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
