L6010 - LAPPACONITINE HBr
(Syn. : Allapinine)
(Syn. : Allapinine)
LAPPACONITINE HBr | Product ID | L6010 |
| Name | LAPPACONITINE HBr |
| Molecular formula | C32H44N2O8.HBr |
| Description |
It is an antagonist of the product L6001 Aconitine as an inhibitor of the voltage-dependent sodium channel. It is also a potent antiarrhythmic. The activity of Lappaconitine hydrobromide is independent of the potential level and of the stimulus intensity. It presents weak affinity at brain Alpha-Bungarotoxin-sensitive nAChR. C18 diterpenoid alkaloid , from plants of the Aconitum genus, Ranunculaceae. |
| Biological activity | It is a selective blocker of the TTX-sensitive Na+ channels, without influence on the activation threshold of Na+ channels. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 10 mg | 125.00 | ||
| 50 mg | 500.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6010 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6010 | Molecular weight | 665.61 g/mol |
| Product name | LAPPACONITINE HBr | Physical form | |
| CAS No. | 97792-45-5 | Melting point | |
| RTECS | AR5569600 | Solubility | In water, ethanol, chloroform Not well in methanol |
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 51346120 | ||
| Purity | 96% | ||
| Toxicity(LD50) | IVN-MUS LD50: 6.1 mg/kg ORL-MUS LD50: 25.0 mg/kg |
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| Chemical Name | [(1S,2S,3S,4S,5R,6S,8S,9S,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl] 2-acetamidobenzoate;hydrobromide | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L6010 |
| Product name | LAPPACONITINE HBr |
- Valeev et al., "Allapinine influence on sodium currents of isolated neurons of trigeminal ganglion and cardiomyocytes of rats." Neurophysiologia (1990) (Russian). 22(2):201-206
Links
| Product code | L6010 |
| Product name | LAPPACONITINE HBr |
| External Links |
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