It is a non-competitive GABA antagonist and a potent convulsant by causing epileptoform seizures.

(IC₅₀) for blocking the GABA-dependent [³⁶Cl] uptake in rat brain synaptosomes: 0.2 nM.

(IC₅₀) for the inhibition of [³H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 μM; (Ticku M.);

(IC₅₀) for the inhibition of [³⁵S]-tert.butyl-thionebicyclophosphate binding with human brain membranes: 480 nM. (Casida J.E.);

experiments with [³H]-labeled GABA-competitive ligands (muscimol, flunitrazepam) showed no influence of Isobicyphat up to 10 μM.

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For research use only — not intended for food, diagnostic or therapeutic use