L6007 - HELIOTRINE
HELIOTRINE | Product ID | L6007 |
| Name | HELIOTRINE |
| Molecular formula | C16H27NO5 |
| Description |
It is an alkaloid used for obtaining models of hepatitis and cirrhosis of the liver. Pyrrolizidine alkaloid, from plants of the Heliotropum genus, Boraginaceae. |
| Biological activity | A single administration of 40 mg/100 g (s.c.) on rats causes an experimental hepatitis for 20 days. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 50 mg | 100.00 | ||
| 250 mg | 400.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6007 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6007 | Molecular weight | 313.16 g/mol |
| Product name | HELIOTRINE | Physical form | Powder |
| CAS No. | 303-33-3 | Melting point | 119-126 °C |
| RTECS | MH6125000 | Solubility | In chloroform Slightly turbid in water |
| UNIPROT | Optical Activity | [alpha]D20 + 57° (chloroform) | |
| PubChem SID | |||
| PubChem CID | 906426 | ||
| Purity | >90% | ||
| Toxicity(LD50) | IPR-RAT (male) LD50: 296 mg/kg IPR-RAT (female) LD50: 478 mg/kg |
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| Chemical Name | [(1s,7ar)-1-hydroxy-2,3,5,7a-tetrahydro-1h-pyrrolizin-7-yl]methyl(2s,3r)-2-hydroxy-3-methoxy-2-(propan-2-yl)butanoate | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
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| Savety Recommandations | For Research Use Only — Not Intended for Diagnostic or Therapeutic Use |
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Bibliographic References
| Product code | L6007 |
| Product name | HELIOTRINE |
- Silvingham et al., Teratogenesis, Carcinogenesis and Mutagenesis (1988). 8:205
- Bruggeman et al., "Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese Hamster cells co-cultured with chick embryo hepatocytes." Mutation Res. (1985). 142:209-212
- Schoental et al., "The effects of the pyrrolizidine alkaloid, heliotrine, and nicotinamide on the concentration of plasma insuline and blood glucose in the rat." Biochem. Soc. Trans. (1976). 4(4):649-650
- Schoental et al., Cancer Res. (1975). 35:2020-2024
- Maltsev. "Study of enzyme oxidative-reducing activity in rat liver in heliotrine chronic intoxication." Pharmacol. and Toxicol. (1971). 2:228-231
- Bull et al., "The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides." J. Path. Bact. (1959). 78:483-502
Links
| Product code | L6007 |
| Product name | HELIOTRINE |
| External Links |
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