ETBICYPHAT
Product ID L9004-1MG 
Name ETBICYPHAT 
Molecular formula C6H11O4P
Description

It is a neuronal voltage-dependent and GABA-gated Cl- channels blocker. It is also a non-competitive GABA antagonist and it causes epileptoform seizures.


Organophosphorous compound , synthetic
Biological activity

Cl- channel total blocking concentration: (IC100) ~ 50 nM (Lymnaea stagnalis);
(IC50) for [3H]-dihydropicrotoxin binding with rat brain membrane P2 fraction: 5.0 μM (Ticku M.);

(IC50) for [35S]-tert.butyl-thionebicyclophosphate binding with human brain membranes : 5.9 μM (Casida J.);

experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Funitrazepam) showed no influence of Etbicyphat up to 10 μM.

 Packaging and Prices

Packaging Price (€) Quantité Buy Now
1 x 1mg 133.00

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5 x 1mg 532.00

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For quotation of big quantities, please Contact us
 Product Technical Documents
Safety Data Sheet Available on request, please Contact us
Ref. SDS_L9004-1MG : unit price : free of charge
 Chemical and Physical Properties
Product code L9004-1MG  Molecular weight 178.12 g/mol
Product name ETBICYPHAT  Physical form
CAS No. 1005-93-2 Melting point 201-202 °C
RTECS TY6475000 Solubility In alcohol and water
UNIPROT Optical Activity
PubChem SID    
PubChem CID 13869    
Purity 95 % (NMR)    
Toxicity(LD50) mice (i.p.): 1.0 mg/kg, (i.v.): 0.35 mg/kg    
Chemical Name 4-ethyl-1-phospha-2,6,7 trioxabicyclo(2.2.2)octane-1-oxide    
Storage & Reconstitution
Recommandations

Store at room temperature


 
Savety Recommandations

For research use only — not intended for food, diagnostic or therapeutic use

 
 Bibliographic References
Product code L9004-1MG 
Product name ETBICYPHAT 

- Bellet et al., Science.(1973) 182:1135-1136
- Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212
- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970
- Squires et al., Mol. Pharmacol.(1983) 23:326-331
 Links
Product code L9004-1MG 
Product name ETBICYPHAT 
External Links PubMed
Biomedical Citations From PubMed
Toxicology Citations From PubMed
PubChem CID
Molecular formula

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