It is a potent inhibitor of Ca²⁺/Mg²⁺ - ATPase.

Ca²⁺ mobilizer: the effect of DTBHQ is to inhibit Ca²⁺ sequestration by the stores and not to stimulate a Ca²⁺ efflux pathway, suggesting that its inhibitory effects on microsomal Ca²⁺-ATPase probably underlies its effects on intracellular Ca²⁺ stores. In permeabilized rat hepatocytes, a maximal concentration (25 μM) mobilized 70 % of sequestered Ca²⁺ and a half-maximal effect was produced by 1.7 μM. 

Although DTBHQ has some selectivity for the Ca²⁺ transport system of Inositol 1,4,5-triphosphate (IP3)-sensitive stores, the selectivity is weak and DTBHQ mobilizes substantially more Ca²⁺ than does a maximally effective concentration of IP3.

Store at room temperature

For research use only — not intended for food, diagnostic or therapeutic use