(Syn. : Gindarine hydrochloride)
TETRAHYDROPALMATINE HCl | Product ID | L6038 |
| Name | TETRAHYDROPALMATINE HCl (d,l)- |
| Molecular formula | C21H25NO4.HCl |
| Description |
It is a D1/D2 Dopaminergic receptors antagonist presenting analgesic and sedative/tranquillizing effects. Diisoquinoline alkaloid , synthetic, originally from Stephania glabra |
| Biological activity | Tetrahydropalmatine presents a sedative/tranquillizing effect, probably due to its antagonistic action on D1/D2 receptors in brain (Vauquelin et al., 1989). The effect of Tetrahydropalmatine on the left auricle of the guinea pig is similar to that of verapamil and antagonistic to calcium. Tetrahydropalmatine mainly inhibits voltage-dependent Ca2+ channels. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 10 mg | 167.00 | ||
| 50 mg | 668.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6038 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6038 | Molecular weight | 391.89 g/mol |
| Product name | TETRAHYDROPALMATINE HCl (d,l)- | Physical form | |
| CAS No. | 6024-85-7 | Melting point | 250-252 °C |
| RTECS | DR9840000 | Solubility | In water |
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 6602555 | ||
| Purity | 95% | ||
| Toxicity(LD50) | ORL-MUS LD50: 1160 mg/kg SCU-MUS LD50: 670 mg/kg ORL-RAT LD50: 930 mg/kg |
||
| Chemical Name | Berbine, 2,3,9,10-tetramethoxy-, hydrochloride, (+-)- | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
||
| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
||
Bibliographic References
| Product code | L6038 |
| Product name | TETRAHYDROPALMATINE HCl (d,l)- |
- Vauquelin et al., "(+-) tetrahydroanisocycline and (+-) tetrahydropalmatine binding to D1 and D2 Dopaminergic receptors in human putamen". Neurochem. Int. (1989) 15(3):321-324
- Marcenac et al. "Effect of l-tetrahydropalmatine on dopamine release and metabolism in the rat striatum." Psychopharmacology (1989). 89:89-93
- Chen et al. "Calcium antagonists from traditional Chinese herbs." Drug News and Perspectives (1990). 3(7):425-428
- Zhao et al. "Effects of dl-Tetrahydropalmatine on contractions of rabbit aortic strips." Acta Pharmacologica Sinica (Chinese; abstract in English) (1988). 9(2):153-155
Links
| Product code | L6038 |
| Product name | TETRAHYDROPALMATINE HCl (d,l)- |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
