L6016 - TETRAHYDROBERBERINE (d,l)-
(Syn. : Canadine)
(Syn. : Canadine)
TETRAHYDROBERBERINE (d,l)- | Product ID | L6016 |
| Name | TETRAHYDROBERBERINE (d,l)- |
| Molecular formula | C20H21NO4 |
| Description |
It is a D1/D2 dopaminergic receptors antagonist with sedative tranquillizing action. As a Tetrahydropalmatine analog, it probably blocks voltage dependent calcium channels. Berberis diisoquinoline alkaloid , synthetic |
| Biological activity | (d,l)-Tetrahydroberberine presents a sedative/tranquillizing effect, probably due to its blocking action on D1/D2 receptors in brain. In contrast with the other non specific D1/D2 receptors blockers, (d,l)-Tetrahydroberberine does not cause catalepsy. (Niwa et al., 1991). (d,l)-Tetrahydroberberine is also probably a calcium antagonist. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 20 mg | 105.00 | ||
| 100 mg | 420.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L6016 : unit price : free of charge |
Chemical and Physical Properties
| Product code | L6016 | Molecular weight | 339.38 g/mol |
| Product name | TETRAHYDROBERBERINE (d,l)- | Physical form | |
| CAS No. | 522-97-4 | Melting point | 168-169 °C |
| RTECS | EX2675000 | Solubility | In chloroform Not well in ethanol and methanol |
| UNIPROT | Optical Activity | ||
| PubChem SID | |||
| PubChem CID | 34458 | ||
| Purity | > 95 % | ||
| Toxicity(LD50) | ORL-MUS LD50: 935 (880-990) mg/kg SCU-MUS LD50: 750 (685-819) mg/kg IVN-MUS LD50: 95 (80-112) mg/kg |
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| Chemical Name | 9,10-Dimethoxy-2,3-(methylenedioxy)berbine | ||
| Storage & Reconstitution Recommandations |
Store at +4°C, in dark place. |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L6016 |
| Product name | TETRAHYDROBERBERINE (d,l)- |
- Niwa et al., "Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate". Parmacology (1991). 43:329-336
- Yamahara "Behavioral pharmacology of berberine-type alkaloids. II. Central depressant effect of tetrahydroberberine (THB) and its related compounds." Folia Pharmacol. Jap. (1976). 72:909-927
Links
| Product code | L6016 |
| Product name | TETRAHYDROBERBERINE (d,l)- |
| External Links |
PubMed
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Toxicology Citations From PubMed
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PubChem CID
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