The strongest sodium channel activator so far

BTX is the most active alkaloid binding at receptor site-2 on sodium channels. It activates the sodium channel even at very negative membrane potentials and keeps it open permanently by preventing channel inactivation. BTX also changes the selectivity of the channel to Na⁺ ions and makes it less selective, enabling larger ions to pass through the pore. EC₅₀ (in vitro): 0.1 to 100 nanomolar. 

BTX binding induces many allosteric effects on other channel regions, and increases the binding of scorpion alpha-toxins to receptor site-3, of Brevetoxin to receptor site-5, and of pyrethroid insecticides to receptor site-7.

Research tool applicable to the study of the function of sodium channel and the effects of other toxins and of a variety of drugs, including anesthetics, analgesics, antiarrhythmics, anticonvulsants and antidepressants.

Stable at room temperature, store preferably at 4°C

For research use only — not intended for food, diagnostic or therapeutic use