It is a potent blocker of voltage-sensitive K⁺ channels. It can also block the Ca²⁺-activated K⁺ channels and it induces GABA release in synaptosomes.

It is a potent inhibitor of various types of voltage-sensitive K⁺ channels. It inhibits the K⁺ channels at the pre and post-synaptic level in the intestinal smooth muscle. It also inhibits Ca²⁺-sensitive K⁺ channels from rat skeletal muscle, incorporated into planar bilayers (Kd = 90 nM in 50 mM KCl). DTX-I would not affect the Ca²⁺ or voltage dependence of gating.
Like beta-BuTX, it affects neurotransmission at the neuromuscular junction by an interaction with pre-synaptic nerve terminals. As a consequence it is a potent convulsant when administered intracerebro-ventricularly.
nM ranges induce GABA release from brain synaptosomes.

Store in saline

For research use only — not intended for food, diagnostic or therapeutic use