CVFk (Cobra Venom Factor) | Product ID | L8122-100UG |
| Name | CVFk (Cobra Venom Factor) |
| Molecular formula | Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits |
| Description |
It is a non-toxic, complement-activating component of cobra venom. Purified from Naja melanoleuca venom, a non-CITES Naja species.
Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits with molecular masses respectively of about 70, 50, and 30 kDa, the two large subunits being glycosylated From Naja kaouthia venom. |
| Biological activity | It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 125.00 | ||
| 5 Unité(s) | 500.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8122-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8122-100UG | Molecular weight | ~ 150 kDa |
| Product name | CVFk (Cobra Venom Factor) | Physical form | Lyophilized |
| CAS No. | 308067-24-5 | Melting point | |
| RTECS | Solubility | PBS pH 7.2, DMSO 10% | |
| UNIPROT | Q91132 | Optical Activity | |
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| Purity | > 95% (HPLC) | ||
| Toxicity(LD50) | |||
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| Storage & Reconstitution Recommandations |
Shipped at ambient temperature under lyophilized powder. In solution, store at -20°C (-4°F). Do not freeze-thaw. Aliquot sample if required and store at -80°C (-112°F).
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use |
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Bibliographic References
| Product code | L8122-100UG |
| Product name | CVFk (Cobra Venom Factor) |
Links
| Product code | L8122-100UG |
| Product name | CVFk (Cobra Venom Factor) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
