L8502-1MG - TETRODOTOXIN Citrate
(Syn. : TTX Citrate, Spheroidine citrate)
(Syn. : TTX Citrate, Spheroidine citrate)
TETRODOTOXIN Citrate | Product ID | L8502-1MG |
| Name | TETRODOTOXIN Citrate |
| Molecular formula | C11H17N3O8 |
| Description |
It is a highly specific Na+ channel blocker in excitable tissues. Purified from Fugu Fish organs (Takifugu oblongus). Lyophilized in citrate buffer (1:5). |
| Biological activity | KD (cardiac myocytes in rats): 0.8 nM 10-8 M block nervous system; 10-5 M block heart muscle. The binding to Na+ channel is reversible. ED50 = 3.7 nM. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 190.00 | ||
| 5 Unité(s) | 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8502-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8502-1MG | Molecular weight | 319.27 g/mol |
| Product name | TETRODOTOXIN Citrate | Physical form | White crystal powder |
| CAS No. | 18660-81-6 | Melting point | It does not melt at 200 °C, darkens and turns black with increasing temperature |
| RTECS | IO1450000 | Solubility | Water soluble |
| UNIPROT | Optical Activity | [α]D - 8.64° (c = 8.55 in dilute acetic acid) | |
| PubChem SID | |||
| PubChem CID | 205806 | ||
| Purity | > 99 % (HPLC), + IR, NMR | ||
| Toxicity(LD50) | IVN-MUS LD50: 7.3 µg/kg IPR-MUS LD50: 8 - 10 µg/kg SCU-MUS LD50: 11.5 µg/kg ORL-MUS LD50: 334 µg/kg ICE-MUS LD50: 600 ng/kg ORL-RBT LD50: 7.5 µg/kg IPR-FRG LD50: 14 µg/kg |
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| Chemical Name | Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol citrate | ||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity. Solution for use: water soluble |
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| Savety Recommandations | For research use only — not intended for food, diagnostic or therapeutic use Highly toxic |
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Bibliographic References
| Product code | L8502-1MG |
| Product name | TETRODOTOXIN Citrate |
- Abraham et al. "Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade." J. Pharmacol. Exp. Ther. (1989). 251(3):1166
- Lombet et al. "A cardiac tetrodotoxin binding component: biochemical identification, characterization and properties." Biochemistry (1981). 20:1279-1285
Links
| Product code | L8502-1MG |
| Product name | TETRODOTOXIN Citrate |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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