L8507-20UG - MAPACALCINE
MAPACALCINE | Product ID | L8507-20UG |
| Name | MAPACALCINE |
| Molecular formula | C407H621N115O131S10 |
| Description |
A 89 amino-acids peptide , natural, purified from Pione vastifica (the Boring sponge). |
| Biological activity | Mapacalcine blocks calcium currents via interaction with a yet unknown target protein. It haas no effect on L-type, T-type, N-type or P/Q-type voltage-gated calcium channels (VGCC). Has no effect on voltage-gated potassium or chloride channels. Blocks non-L-type VGCC calcium currents in mouse duodenal myocytes (IC50=0.2 µM). Blocks calcium influx induced by hypoxia/reoxygenation in rat hepatocytes. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 120.00 | ||
| 5 Unité(s) | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8507-20UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8507-20UG | Molecular weight | 9535.27 Da |
| Product name | MAPACALCINE | Physical form | White lyophilized solid |
| CAS No. | Melting point | ||
| RTECS | Solubility | water and saline buffer | |
| UNIPROT | P86916 | Optical Activity | |
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| Purity | |||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8507-20UG |
| Product name | MAPACALCINE |
- "1. ""Purification of a new dimeric protein from Cliona vastifica sponge, which specifically blocks a non-L-type calcium channel in mouse duodenal myocytes."", Morel J.L., Drobecq H., Sautiere P., Tartar A., Mironneau J., Qar J., Lavie J.L., Hugues M., Mol. Pharmacol. 51:1042-1052(1997)
2.""125I-Labelled mapacalcine: a specific tool for a pharmacological approach to a receptor associated with a new calcium channel on mouse intestinal membranes."", Vidalenc P., Morel J.L., Mironneau J., Hugues M., Biochem. J. 331:177-184(1998)
3.""Distribution of mapacalcine receptors in the central nervous system of rat using the [125I]-labeled mapacalcine derivative."", Mourre C., Mokrzycki N., Neuilly G., Richeux F., Creppy E.E., Hugues M. Brain Res. 858:136-142(2000)
4.""Characterization of mapacalcine-sensitive Ca(2+) channels in rat kidney."", Mourre C., Lazou B., Cambar J., Neuilly G., Hugues M., Biochem. Biophys. Res. Commun. 308:602-607(2003)
5.""Mapacalcine specifically blocks hypoxia-induced calcium influx in rat hepatocytes."", Crenesse D., Neuilly G., Gugenheim J., Ferre C., Hugues M., Eur. J. Biochem. 270:1952-1957(2003)"
Links
| Product code | L8507-20UG |
| Product name | MAPACALCINE |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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