DERMASEPTINE B2 - Latoxan Valence France

DERMASEPTINE B2

Product ID

L8302-500UG

Name

DERMASEPTINE B2

Molecular formula

C₁₅₆H₂₇₆N₅₆O₄₆S₆

Description

A 33 amino-acids peptide , natural, isolated from the skin of Phyllomedusa bicolor, the giant leaf frog.

Biological activity

Dermaseptins are typically 27-34 amino acid residues in length and were the first vertebrate peptides demonstrated as having a lethal effect on the filamentous fungi implicated in severe opportunistic infections accompanying immunodeficiency syndrome and immunosuppressive drug therapy. practical: CMi de 0.3 à 50 µMol.
Adenoregulin (Dermasptine B2) enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria.
Adenoregulin shows a potent antimicrobial activity against bacteria, fungi and protozoa. Lacks hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure.

Packaging and Prices

Packaging	Price (€)	Buy Now
1 Unité(s)	675.00	add to cart
5 Unité(s)	2 700.00	add to cart
For quotation of big quantities, please Contact us

Product Technical Documents

	Safety Data Sheet Available on request, please Contact us Ref. SDS_L8302-500UG : unit price : free of charge

Chemical and Physical Properties

Product code	L8302-500UG	Molecular weight	3181.68 Da
Product name	DERMASEPTINE B2	Physical form	White lyophilized solid
CAS No.	149260-68-4	Melting point
RTECS		Solubility	Soluble in water.
UNIPROT	P31107	Optical Activity
PubChem SID
PubChem CID	16130875
Purity	99 %
Toxicity(LD50)	No Data
Chemical Name	Dermaseptin B2, DRS-B2, Adenoregulin
Storage & Reconstitution Recommandations	Store preferably at -20°C. Solid and solutions can be kept in deep freeze for a long time without any change in their activity.
Savety Recommandations

Bibliographic References

Product code	L8302-500UG
Product name	DERMASEPTINE B2

- 1. Daly JW, Caceres J, Moni RW, Gusovsky F, Moos M Jr, Seamon KB, Milton K, Myers CW. Frog secretions and hunting magic in the upper Amazon: identification of a peptide that interacts with an adenosine receptor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10960-3.
2. Mor A, Amiche M, Nicolas P. Structure, synthesis, and activity of dermaseptin b, a novel vertebrate defensive peptide from frog skin: relationship with adenoregulin Biochemistry. 1994 May 31;33(21):6642-50.
3. Amiche, M., Ducancel, F., Mor, A., Boulain, J.C., Menez, A. and Nicolas, P. « Precursors of vertebrate peptide antibiotics, dermaseptin b and adenoregulin show considerable sequence identities with precursors for the opioid peptides, dermorphin, dermenkephalin and deltorphins. » J. Biol. Chem (1994) 269 N°27,17847-17852.
4. Olivier Lequin, Francine Bruston, Odile Convert, Gerard Chassaing, and Pierre Nicolas. « Helical Structure of Dermaseptin B2 in a Membrane-Mimetic Environment » Biochemistry 2003, 42, 10311-10323.

Links

Product code	L8302-500UG
Product name	DERMASEPTINE B2
External Links	PubMed
	Biomedical Citations From PubMed
	Toxicology Citations From PubMed

	PubChem CID
	UNIPROT

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