L8508-100UG - CONOTOXIN GVIA (omega-)
(Syn. : SNX-124, Shaker peptide)
(Syn. : SNX-124, Shaker peptide)
CONOTOXIN GVIA (omega-) | Product ID | L8508-100UG |
| Name | CONOTOXIN GVIA (omega-) |
| Molecular formula | C120H187N37O41S6 |
| Description |
A 27 Amino-Acids peptide with 3 disulfide bonds , synthetic, originally isolated from Conus geographus molluscan venom. |
| Biological activity | ω-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). ω-conotoxin GVIA blocks N-type calcium channels (Cav2.2/CACNA1B) with a high potency (it displaces [125I]GVIA with an IC50=3.7-38 pM) |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 160.00 | ||
| 5 Unité(s) | 640.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8508-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8508-100UG | Molecular weight | 2994.2 Da |
| Product name | CONOTOXIN GVIA (omega-) | Physical form | White lyophilized solid |
| CAS No. | 106375-28-4 | Melting point | |
| RTECS | Solubility | water and saline buffer | |
| UNIPROT | P01522 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 16133838 | ||
| Purity | > 98 % (HPLC) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Shipped at ambient temperature under lyophilized powder. Store at -20°C (-4°F). Do not freeze-thaw. Aliquot sample if required and store at -80°C (-112°F) |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8508-100UG |
| Product name | CONOTOXIN GVIA (omega-) |
- 1. Lew, M. J., Flinn et al. (1997) Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues, J Biol Chem 272, 12014-12023.
2. Sevilla, P et al. (1993) Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR, Biochem Biophys Res Commun 192,1238-1244.
3. Nishiuchi, Y., et al. (1986) Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds, Biopolymers 25 Suppl, S61-68.
4. Olivera, B. M., et al. (1984) Purification and sequence of a presynaptic peptide toxin from Conus geographus venom, Biochemistry 23, 5087-5090.
5. Seiji lchida et al. (2005) Characteristics of Omega-conotoxin GVI A and MVllC Binding to Cav 2.1 and Cav 2.2 Channels Captured by Anti-Ca2+ Channel Peptide Antibodies, Neurochemicol Research 30, 457-466
Links
| Product code | L8508-100UG |
| Product name | CONOTOXIN GVIA (omega-) |
| External Links |
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