L8205-10UG - CHLOROTOXIN (Synthetic)
(Syn. : CTX, ClTx)
(Syn. : CTX, ClTx)
CHLOROTOXIN (Synthetic) | Product ID | L8205-10UG |
| Name | CHLOROTOXIN (Synthetic) |
| Molecular formula | C158H256N52O48S11 |
| Description |
A 36 amino-acids peptide with 4 disulfide bridges , synthetic, originally isolated from Leiurus quinquestriatus scorpion venom. |
| Biological activity | ClTx binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae. It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface. A total resistance is found in skeletal muscle cells. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 x 10µg | 29.00 | ||
| 5 x 10µg | 116.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8205-10UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8205-10UG | Molecular weight | 4001.61 Da |
| Product name | CHLOROTOXIN (Synthetic) | Physical form | White lyophilized solid |
| CAS No. | 163515-35-3 | Melting point | |
| RTECS | Solubility | well in water and saline. | |
| UNIPROT | P45639 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 86278273 | ||
| Purity | 95.5 % (HPLC). | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable in freeze-dried state. In solution, keep at -20°C. |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8205-10UG |
| Product name | CHLOROTOXIN (Synthetic) |
- "1. DeBin et al., ""Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion."" Am. J. Physiol. 264 (Cell Physiol. 33):C361-C369 (1993).
2. Lippens et al., ""NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels."" Biochemistry 34:13-21 (1995).
3. J. Najib, P. Sautière, J.C. Gesquière and A. Tartar, ""Innovation and Perspective in Solid Phase Synthesis"", R. Epton, Mayflower Worldwide, Birmingham 615 (1994)"
Links
| Product code | L8205-10UG |
| Product name | CHLOROTOXIN (Synthetic) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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