L8528-100UG - ShK-Dap22
(Syn. : Potassium channel toxin ShK-Dap22, (Dap22)-kappa-Stichotoxin-She3a, (Dap22)-kappa-SHTX-She3a)
(Syn. : Potassium channel toxin ShK-Dap22, (Dap22)-kappa-Stichotoxin-She3a, (Dap22)-kappa-SHTX-She3a)
ShK-Dap22 | Product ID | L8528-100UG |
| Name | ShK-Dap22 |
| Molecular formula | C166H268N54O48S7 |
| Description |
A 35 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Sun anemone Stichodactyla helianthus. |
| Biological activity | ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4), and Kv1.6 (KCNA6) respectively with a Kd of 11 pM,16 pM, 312 pM and 165 pM. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 170.00 | ||
| 5 Unité(s) | 680.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8528-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8528-100UG | Molecular weight | 4012.8 Da |
| Product name | ShK-Dap22 | Physical form | White lyophilized solid |
| CAS No. | 220384-25-8 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | NA | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488816 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8528-100UG |
| Product name | ShK-Dap22 |
- 1. Beeton C., et al. (2001) Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis. Proc Natl Acad Sci USA. ;
2. Kalman K, et al. (1998) ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem. ;
3. Lanigan MD., et al. (2002) Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. Biochemistry. ;
4. Middleton RE., et al. (2003) Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile. Biochemistry. ;
5. Norton RS., et al. (2004) Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases. Curr Med Chem. ;
6. Robbins JR., et al. (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels. J Physiol.
Links
| Product code | L8528-100UG |
| Product name | ShK-Dap22 |
| External Links |
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