(Syn. : Delta-Kappa-actitoxin-Avd4a, Blood-depressing substance-1)
BDS-I | Product ID | L8524-100UG |
| Name | BDS-I |
| Molecular formula | C210H297N57O56S6 |
| Description |
A 43 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Mediterranean snakelocks sea anemone Anemonia sulcata. |
| Biological activity | Delta-Kappa-actitoxin-Avd4a (BDS-1) acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) and slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A. BDS-I inhibits all Kv3.1, Kv3.2 and Kv3.4 by 45%, 48% and 56% respectively when tested at a voltage of +40 mV. BDS-1 is a selective gating activator of the human Nav1.7/SCN9A channel subtype, an important target for pain management. This toxin does not have effect on Nav1.1/SCN1A and Nav1.6/SCN8A sodium channels. It has little or no functional effect on cardiac muscle, as well as on skeletal muscle myotubes, suggesting lack of functional interaction with Nav1.4/SCN4A or Nav1.5/SCN5A. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 90.00 | ||
| 5 Unité(s) | 360.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8524-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8524-100UG | Molecular weight | 4708.37 Da |
| Product name | BDS-I | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P11494 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90489021 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8524-100UG |
| Product name | BDS-I |
- 1. Diochot et al (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J.Biol.Chem. ;
2. Martina M., et al. (2007) Voltage-dependent potassium currents during fast spikes of rat cerebellar Purkinje neurons: inhibition by BDS-I toxin. J. Neurophysiol. ;
3. Pannaccione et al (2007) Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol.Pharmacol. ;
4. Pin Liu, Sooyeon Jo, Bruce P. Bean. Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. Journal of Neurophysiology 107, 3155-3167 (2012). ;
5. Shuk Yin M. Yeung, Dawn Thompson, Zhuren Wang, David Fedida, Brian Robertson. Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. The Journal of Neuroscience 25, 8735-8745 (2005).
Links
| Product code | L8524-100UG |
| Product name | BDS-I |
| External Links |
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