L8523-100UG - NMB-1
(Syn. : Noxious mechanosensation blocker 1)
(Syn. : Noxious mechanosensation blocker 1)
NMB-1 | Product ID | L8523-100UG |
| Name | NMB-1 |
| Molecular formula | C111H164N36O21S4 |
| Description |
A 19 amino-acids peptide with 2 disulfide bridges. Synthetic analog of cone snail toxin of ?-Conotoxin TIA isolated from the venom of the Tulip cone snail Conus tulipa. |
| Biological activity | NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting (SA) mechanically activated currents over rapidly adapting (RA) ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 µM. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8523-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8523-100UG | Molecular weight | 2467.03 Da |
| Product name | NMB-1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | NA | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
||
| Savety Recommandations | |||
Bibliographic References
| Product code | L8523-100UG |
| Product name | NMB-1 |
- 1. Delmas P., et al. (2011). Molecular mechanisms of mechanotransduction in mammalian sensory neurons. Nature ;
2. Drew LJ., et al. (2007). High-Threshold Mechanosensitive Ion Channels Blocked by a Novel Conopeptide Mediate Pressure-Evoked Pain. PLoS ONE
Links
| Product code | L8523-100UG |
| Product name | NMB-1 |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
 UNIPROT |
