L8520-100UG - CONOTOXIN PIIIA (mu-)
(Syn. : Mu-conotoxin P3.7)
(Syn. : Mu-conotoxin P3.7)
CONOTOXIN PIIIA (mu-) | Product ID | L8520-100UG |
| Name | CONOTOXIN PIIIA (mu-) |
| Molecular formula | C103H165N40O28S6 |
| Description |
A 22 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Purple cone snail Conus purpurascens. |
| Biological activity | μ-Conotoxin PIIIA potently blocks rNav1.4/SCN4A (IC50=36-41 nM). It also moderately blocks rNav1.1/SCN1A (IC50=120 nM), rNav1.2/SCN2A (IC50=620 nM), rNav1.3/SCN3A (IC50=3.2 µM), mNav1.6/SCN8A (IC50=100 nM). This inhibition is reversible. This toxin does not or only weakly blocks rNav1.5/SCN5A, rNav1.7/SCN9A (IC50=3.1-6.2 µM and >100 µM), and rNav1.8/SCN10A. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8520-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8520-100UG | Molecular weight | 2604.10 Da |
| Product name | CONOTOXIN PIIIA (mu-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P58925 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % (HPLC) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8520-100UG |
| Product name | CONOTOXIN PIIIA (mu-) |
- 1. Chen R., et al. (2014) Mechanism of ?-Conotoxin PIIIA Binding to the Voltage-Gated Na+ Channel NaV1.4. PLoS One. PMID 24676211 ;
2. Nielsen, K. J., et al. (2002) Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels, J Biol Chem. ;
3. Safo, P., et al. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA, J Neurosci. ;
4. Shon, K. J., et al. (1998) mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes, J Neurosci.
Links
| Product code | L8520-100UG |
| Product name | CONOTOXIN PIIIA (mu-) |
| External Links |
PubMed
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Toxicology Citations From PubMed
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