L8518-500UG - CONOTOXIN-PeIA
(Syn. : alpha-Conotoxin PeIA)
(Syn. : alpha-Conotoxin PeIA)
CONOTOXIN-PeIA | Product ID | L8518-500UG |
| Name | CONOTOXIN-PeIA alpha- |
| Molecular formula | C65H98N22O21S4 |
| Description |
A 16 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Grand cone snail Conus pergrandis. |
| Biological activity | This synthetic peptide potently and reversibly blocks alpha-9-alpha-10 nAChR (IC50=6.9-54.9 nM), alpha-3-beta-2 (IC50=9.7-97.5 nM) and alpha-6/alpha-3-beta-2-beta-3 (IC50=11.1-17.2 nM) . Also shows a weak inhibition of alpha-6/alpha-3-beta-4 (IC50=147 nM) and alpha-3-beta-4 (IC50=480-1500 nM). Alpha-conotoxin PeIA also inhibits N-type calcium channels (Ca2.2/CACNA1B) (IC50=1.1 nM) via the activation of the G protein-coupled GABA(B) receptor in DRG neurons. Alpha-conotoxin PeIA shows a very weak or no inhibition on muscle alpha-1-beta-1-gamma-delta, neuronal alpha-7, and neuronal alpha-4-beta-2 nAChR. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8518-500UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8518-500UG | Molecular weight | 1651.9 Da |
| Product name | CONOTOXIN-PeIA alpha- | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | Q1L777 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8518-500UG |
| Product name | CONOTOXIN-PeIA alpha- |
- 1. Day N., et al. (2011) Structure and Activity of ?-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABAB Receptor-coupled N-type Calcium Channels. JBC. ;
2. McIntosh M., et al. (2005) A novel ?-conotoxin, PeIA, cloned from Conus Pergrandis, discriminates between rat ?9?10 and ?7 nicotinic cholinergic receptor. JBC.
Links
| Product code | L8518-500UG |
| Product name | CONOTOXIN-PeIA alpha- |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
