L8517-100UG - C-CONOTOXIN-PrXA
(Syn. : Alpha C-PrXA)
Product ID |
L8517-100UG |
Name |
C-CONOTOXIN-PrXA alpha- |
Molecular formula |
C160H249N43O44S2 |
Description |
A 32 amino-acids peptide with 1 disulfide bridge
, synthetic, initially isolated from the venom of the Parian cone snail Conus parius.
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Biological activity |
α-C-Conotoxin PrXA potently antagonizes mouse muscle adult α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 = 3 nM). α-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces (with higher affinity however for the α/δ subunit interface such as α-conotoxin GI and α-conotoxin MI). |
| Safety Data Sheet Available on request, please Contact us Ref. SDS_L8517-100UG : unit price : free of charge |
Product code |
L8517-100UG |
Molecular weight |
3541.1 Da |
Product name |
C-CONOTOXIN-PrXA alpha- |
Physical form |
White lyophilized solid |
CAS No. |
NA |
Melting point |
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RTECS |
NA |
Solubility |
water and saline buffer |
UNIPROT |
P0C8S5 |
Optical Activity |
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PubChem SID |
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PubChem CID |
NA |
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Purity |
> 98 % |
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Toxicity(LD50) |
No Data |
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Chemical Name |
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Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C
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Savety Recommandations |
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Product code |
L8517-100UG |
Product name |
C-CONOTOXIN-PrXA alpha- |
- 1. Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists. Biochemistry. ;
2. Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors. Philippine Science Letters