CONOTOXIN CnIIIC (mu-) | Product ID | L8514-100UG |
| Name | CONOTOXIN CnIIIC (mu-) |
| Molecular formula | C92H141N35O28S6 |
| Description |
A 22 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Singed cone snail Conus consors. |
| Biological activity | µ-conotoxin CnIIIC inhibits the skeletal muscle rNav1.4/SCN4A (IC50=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC50=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, it decreases twitch tension in mouse hemidiaphragms (IC50=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50=46 nM). |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 120.00 | ||
| 5 Unité(s) | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8514-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8514-100UG | Molecular weight | 2375.8 Da |
| Product name | CONOTOXIN CnIIIC (mu-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | I1SB07 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8514-100UG |
| Product name | CONOTOXIN CnIIIC (mu-) |
- 1. Favreau P., et al. (2012) A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. BJP. ;
2. Markgraf R., et al. (2012) Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. BJP.
Links
| Product code | L8514-100UG |
| Product name | CONOTOXIN CnIIIC (mu-) |
| External Links |
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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