L8513-500UG - CONOTOXIN BuIA (alpha-)
CONOTOXIN BuIA (alpha-) | Product ID | L8513-500UG |
| Name | CONOTOXIN BuIA (alpha-) |
| Molecular formula | C54H82N14O16S4 |
| Description |
A 13 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Bubble cone snail Conus bullatus. |
| Biological activity | α-Conotoxin BuIA potently blocks numerous mammalian nAChR subtypes: alpha-6/alpha-3-beta-2 (CHRNA6/CHRNA3-CHRNB2) (IC50=0.258 nM) > alpha-6/alpha-3-beta-4 (CHRNA6/CHRNA3-CHRNB4) (IC50=1.54 nM) > alpha-3-beta-2 (CHRNA3-CHRNB2) (IC50=5.72 nM) > alpha-3-beta-4 (CHRNA3-CHRNB4)(IC50=27.7 nM) > alpha-4-beta-4 (CHRNA4-CHRNB4) (IC50=69.9 nM) > alpha-2-beta-4 (CHRNA2-CHRNB4) (IC50=121 nM) > alpha-7 (CHRNA7) (IC50=272 nM) > alpha-2-beta-2 (CHRNA2-CHRNB2) (IC50=800 nM). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. This toxin represents a novel probe for distinguishing between beta-2 and beta-4 subunit-containing nAChRs. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 150.00 | ||
| 5 Unité(s) | 600.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8513-500UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8513-500UG | Molecular weight | 1311.59 Da |
| Product name | CONOTOXIN BuIA (alpha-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P69657 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8513-500UG |
| Product name | CONOTOXIN BuIA (alpha-) |
- 1. Azam L., et al. (2004) ?-Conotoxin BuIA, a Novel Peptide from Conus bullatus, Distinguishes among Neuronal Nicotinic Acetylcholine Receptors. JBC ;
2. Shiembob D., et al. (2006) Determinants of ?-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor ? subunit. Biochemistry
Links
| Product code | L8513-500UG |
| Product name | CONOTOXIN BuIA (alpha-) |
| External Links |
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Toxicology Citations From PubMed
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