L8512-100UG - CONOTOXIN GIIIB (mu-)
CONOTOXIN GIIIB (mu-) | Product ID | L8512-100UG |
| Name | CONOTOXIN GIIIB (mu-) |
| Molecular formula | C101H175N39O30S7 |
| Description |
A 22 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus. |
| Biological activity | µ-conotoxin GIIIB selectively blocks Nav1.4 voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM. µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 120.00 | ||
| 5 Unité(s) | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8512-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8512-100UG | Molecular weight | 2640.26 Da |
| Product name | CONOTOXIN GIIIB (mu-) | Physical form | White lyophilized solid |
| CAS No. | 140678-12-2 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P01524 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90469965 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8512-100UG |
| Product name | CONOTOXIN GIIIB (mu-) |
- 1. Cruz LJ, et al. (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels. JBC. ;
2. Gregory N. Filatov and Mark M. Rich (2004) Hyperpolarized shifts in the voltage dependence of fast inactivation of Nav1.4 and Nav1.5 in a rat model of critical illness myopathy. J. Physiol. ;
3. Ronald A. Li, et al. (2003) Molecular Basis of Isoform-specific ?-Conotoxin Block of Cardiac, Skeletal Muscle, and Brain Na+ Channels. JBC. ;
4. Ronald A. Li, et al. (2000) Novel Structural Determinants of m-Conotoxin (GIIIB) Block in Rat Skeletal Muscle (m1) Na+ Channels. JBC.
Links
| Product code | L8512-100UG |
| Product name | CONOTOXIN GIIIB (mu-) |
| External Links |
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