L8511-1MG - CONANTOKIN-G-1MG
CONANTOKIN-G-1MG | Product ID | L8511-1MG |
| Name | CONANTOKIN-G-1MG |
| Molecular formula | C88H138N26O44 |
| Description |
A 17 amino-acids peptide , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus. |
| Biological activity | Conantokin-G selectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Induces sleep-like symptoms in young mice and hyperactivity in older mice. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 180.00 | ||
| 5 Unité(s) | 720.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8511-1MG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8511-1MG | Molecular weight | 2264.23 Da |
| Product name | CONANTOKIN-G-1MG | Physical form | White lyophilized solid |
| CAS No. | 93438-65-4 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P07231 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 16181638 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8511-1MG |
| Product name | CONANTOKIN-G-1MG |
- 1. Alex AB., et al. (2011) CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors. Neurotoxicology. ;
2. Blandl T., et al. (1998) NMDA-receptor antagonist requirements in conantokin-G. FEBS Lett.  ;
3. Blandl, T., et al. (1999) Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T, J Pept Res. ;
4. Donevan SD., et al. (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol Pharmacol. ;
5. Kabanova NV, et al. (2012) Balsara R., et al. (2012) Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. Neuropharmacology. ;
6. Klein, R. C.,et al. (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors, J Biol Chem. ;
7. Malmberg, AB., et al. (2003) Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T, Pain. ;
8. Mena EE., et al. (1990) Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor. Neurosci Lett. PMID: 2177176 ;
9. Sheng Z., et al. (2009) The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.  Neuropharmacology.  PMID: 19427876 ;
10. Sheng Z., et al. (2010) Specific determinants of conantokins that dictate their selectivity for the NR2B subunit of N-methyl-D-aspartate receptors. Neuroscience.
Links
| Product code | L8511-1MG |
| Product name | CONANTOKIN-G-1MG |
| External Links |
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