L8510-100UG - CONOTOXIN GID (alpha-)
(Syn. : alpha-Conotoxin GID)
(Syn. : alpha-Conotoxin GID)
CONOTOXIN GID (alpha-) | Product ID | L8510-100UG |
| Name | CONOTOXIN GID (alpha-) |
| Molecular formula | C84H135N31O30S4 |
| Description |
A 19 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Geographer cone snail Conus geographus. |
| Biological activity | α-conotoxin GID reversibly blocks alpha-3-beta-2/CHRNA3-CHRNB2 (IC50=3.1-5.1 nM), alpha-7/CHRNA7 (IC50=4.5-5.1 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC50=128.6-390 nM) nAChRs. It does not inhibit neuronal alpha-3-beta-4/CHRNA3-CHRNB4 and alpha-4-beta-4/CHRNA4-CHRNB4 nAChR, and muscle alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRND nAChR. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 170.00 | ||
| 5 Unité(s) | 680.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8510-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8510-100UG | Molecular weight | 2185.45 Da |
| Product name | CONOTOXIN GID (alpha-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P60274 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8510-100UG |
| Product name | CONOTOXIN GID (alpha-) |
- 1. Banerjee J., et al. (2014) Design and synthesis of ?-conotoxin GID analogues as selective ?4?2 nicotinic acetylcholine receptor antagonists. Biopolymers. ;
2. Leffler, A. E., et al. (2017). Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. PNAS, 114(38), 8100–8109. doi: 10.1073/pnas.1703952114. ;
3. Millard E., et al. (2009) Inhibition of Neuronal Nicotinic Acetylcholine Receptor Subtypes by ?-Conotoxin GID and Analogues. JBC. ;
4. Nicke A., et al. (2003) Isolation, Structure, and Activity of GID, a Novel 4/7-Conotoxin with an Extended N-terminal Sequence. JBC.Â
Links
| Product code | L8510-100UG |
| Product name | CONOTOXIN GID (alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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