L8505-500UG - CONOTOXIN-MI (alpha-)
(Syn. : alpha-Conotoxin MI)
(Syn. : alpha-Conotoxin MI)
CONOTOXIN-MI (alpha-) | Product ID | L8505-500UG |
| Name | CONOTOXIN-MI (alpha-) |
| Molecular formula | C58H88N22O17S4 |
| Description |
A 14 amino-acids peptide with 2 disulfide bridges , synthetic, initially isolated from the venom of the Magical cone snail Conus magus. |
| Biological activity | α-conotoxin MI is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors (nAChR). It blocks mammalian nAChR composed of alpha-1/delta subunits with high potency and alpha-1/gamma with a low potency, allowing to distinguish between the two agonist sites as it binds 10,000-fold more tightly to the α/δ than to the α/γ site. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 90.00 | ||
| 5 Unité(s) | 360.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8505-500UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8505-500UG | Molecular weight | 1495.08 Da |
| Product name | CONOTOXIN-MI (alpha-) | Physical form | White lyophilized solid |
| CAS No. | 88217-10-1 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P01521 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 25081090 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8505-500UG |
| Product name | CONOTOXIN-MI (alpha-) |
- 1. Jacobsen, R.B., et al. (1999) Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors, Biochemistry. ;
2. Gray, W. R., et al. (1983) Conotoxin MI. Disulfide bonding and conformational states, J Biol Chem. ;
3. Papineni RV., et al. (2001) Site-specific charge interactions of alpha-conotoxin MI with the nicotinic acetylcholine receptor. J Biol Chem.
Links
| Product code | L8505-500UG |
| Product name | CONOTOXIN-MI (alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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 UNIPROT |
