L8442-100UG - PROTOXIN I
(Syn. : ProTx-I, beta/omega-theraphotoxin-Tp1a, beta/omega-TRTX-Tp1a)
(Syn. : ProTx-I, beta/omega-theraphotoxin-Tp1a, beta/omega-TRTX-Tp1a)
PROTOXIN I | Product ID | L8442-100UG |
| Name | PROTOXIN I |
| Molecular formula | C171H245N53O47S6 |
| Description |
A 35 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Peruvian green velvet tarantula Thrixopelma pruriens. |
| Biological activity | Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. Protoxin I also antagonizes the TRPA1 Nociceptor Ion Channel by binding to its S1-S4 gating domain. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 90.00 | ||
| 5 Unité(s) | 360.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8442-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8442-100UG | Molecular weight | 3987.50 Da |
| Product name | PROTOXIN I | Physical form | White lyophilized solid |
| CAS No. | 484598-35-8 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P83480 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488963 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8442-100UG |
| Product name | PROTOXIN I |
- 1. Gui J, et al. (2014) A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1-S4 Gating Domain. Curr Biol. ;
2. Middleton R. E., et al. (2002) Two tarantula peptides inhibit activation of multiple sodium channels, Biochemistry. ;
3. Ohkubo T, et al. (2010) Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ Channels Cav3.1 and Cav3.2. J Pharmacol Sci. ;
4. Priest B. T., et al. (2007) ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels, Toxicon. ;
5. 17087985Klint JK., et al. (2012) Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads. Toxicon.
Links
| Product code | L8442-100UG |
| Product name | PROTOXIN I |
| External Links |
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Toxicology Citations From PubMed
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