L8441-100UG - STROMATOXIN-1
(Syn. : ScTx-1, kappa-theraphotoxin-Sc1a, kappa-TRTX-Sc1a)
(Syn. : ScTx-1, kappa-theraphotoxin-Sc1a, kappa-TRTX-Sc1a)
STROMATOXIN-1 | Product ID | L8441-100UG |
| Name | STROMATOXIN-1 |
| Molecular formula | C156H237N49O48S7 |
| Description |
A 34 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Featherleg baboon spider Stromatopelma calceatum. |
| Biological activity | Stromatoxin-1 (ScTx1) acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC50 is 12.7 nM), Kv2.1/Kv9.3 (IC50 is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC50 is 21.4 nM), and transient Kv4.2/KCND2 (IC50 is 1.2 nM) channels. Stromatoxin-1 has no effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6 or Kv3.4 channels. The toxin has also no effect on voltage-dependent Na+ and Ca2+ channels of cerebellar granule cells. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 140.00 | ||
| 5 Unité(s) | 560.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8441-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8441-100UG | Molecular weight | 3791.3 Da |
| Product name | STROMATOXIN-1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P60991 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | No Data | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
||
| Savety Recommandations | |||
Bibliographic References
| Product code | L8441-100UG |
| Product name | STROMATOXIN-1 |
- 1. Braun M., et al. (2008)Â Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes. ;
2. Chen M., et al. (2013) Voltage-gated K+ channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle. Am J Physiol Regul Integr Comp Physiol. ;
3. Druzin M., et al. (2011) Mechanism of estradiol-induced block of voltage-gated K+ currents in rat medial preoptic neurons. PLoS One. ;
4. Escoubas P., et al. (2002)Â Novel Tarantula Toxins for Subtypes of Voltage-Dependent Potassium Channels in the Kv2 and Kv4 Subfamilies. Mol Pharm. ;
5. Guan D., et al. (2011) Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons. J Neurophysiol. ;
6. Hristov KL., et al. (2012) KV2.1 and electrically silent KV channel subunits control excitability and contractility of guinea pig detrusor smooth muscle. Am J Physiol Cell Physiol. ;
7. Ramracheya R., et al. (2010)Â Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes. ;
8. Schiau YS., et al. (2003) Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels. Chem Res Toxicol. ;
9. Tsantoulas C., et al. (2014) Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input. Exp Neurol. ;
10. Zhong XZ., et al. (2010)Â Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter. J Physiol. ;
11. Zhong XZ., et al. (2010) Stromatoxin-sensitive, heteromultimeric Kv2.1/Kv9.3 channels contribute to myogenic control of cerebral arterial diameter. J Physiol.
Links
| Product code | L8441-100UG |
| Product name | STROMATOXIN-1 |
| External Links |
PubMed
|
|
Biomedical Citations From PubMed
|
|
|
Toxicology Citations From PubMed
|
|
|
PubChem CID
|
|
 UNIPROT |
