L8433-100UG - HUWENTOXIN-I
(Syn. : HwTx-I, mu/omega-theraphotoxin-Hs1a, mu/omega-TRTX-Hs1a)
(Syn. : HwTx-I, mu/omega-theraphotoxin-Hs1a, mu/omega-TRTX-Hs1a)
HUWENTOXIN-I | Product ID | L8433-100UG |
| Name | HUWENTOXIN-I |
| Molecular formula | C161H246N48O44S6 |
| Description |
A 33 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese gold earth tiger spider Ornithoctonus huwena, also known as Cyriopagopus schmidti, Haplopelma schmidti, Haplopelma huwenum. |
| Biological activity | An inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect's DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and virtually no effect on muscle sodium channels. Huwentoxin-I showed an antinociceptive effect in rat. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 170.00 | ||
| 5 Unité(s) | 680.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8433-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8433-100UG | Molecular weight | 3751.77 Da |
| Product name | HUWENTOXIN-I | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P56676 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8433-100UG |
| Product name | HUWENTOXIN-I |
- 1. Chen JQ., et al. (2005) Antinociceptive effects of intrathecally administered huwentoxin-I, a selective N-type calcium channel blocker, in the formalin test in conscious rats. ;
2. Liang, S. P., et al. (1993) Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon. ;
3. Liang, S. P., et al. (2000) The presynaptic activity of huwentoxin-I, a neurotoxin from the venom of the chinese bird spider Selenocosmia huwena, Toxicon. ;
4. Peng, K., et al. (2001) The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108-15 cells, a patch-clamp study, Toxicon. ;
5. Wang M, et al. (2012) The effects of huwentoxin-I on the voltage-gated sodium channels of rat hippocampal and cockroach dorsal unpaired median neurons. Peptides. ;
6. Wang M, et al. (2007) The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons. Biochem Biophys Res Commun. ;
7. Wang YR, et al. (2007) Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia. Toxicon. ;
8. Wen Tao Z, et al. (2011) The antinociceptive efficacy of HWTX-I epidurally administered in rheumatoid arthritis rats. Int J Sports Med. PMID: 22052031 ;
9. Zhou, P. A., et al. (1997) Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena, Toxicon. PMID: 9028007
Links
| Product code | L8433-100UG |
| Product name | HUWENTOXIN-I |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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