L8432-100UG - HAINANTOXIN-IV
(Syn. : mu-theraphotoxin-Hhn1b 1, mu-TRTX-Hhn1b, Peptide F8-18.88, HnTx-IV)
(Syn. : mu-theraphotoxin-Hhn1b 1, mu-TRTX-Hhn1b, Peptide F8-18.88, HnTx-IV)
HAINANTOXIN-IV | Product ID | L8432-100UG |
| Name | HAINANTOXIN-IV |
| Molecular formula | C166H257N53O50S6 |
| Description |
A 35 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese black earth tiger spider Haplopelma hainanus, also known as Cyriopagopus hainanus. |
| Biological activity | Hainantoxin-IV (HNTX-IV) is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50 value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8432-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8432-100UG | Molecular weight | 3987.6 Da |
| Product name | HAINANTOXIN-IV | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | D2Y232 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8432-100UG |
| Product name | HAINANTOXIN-IV |
- 1. Li D, et al.(2004) Structure–activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers. J Biol Chem. ;
2. Liu Y, et al. (2012) A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels. J Pept Sci. ;
3. Liu Z, et al.(2003) Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana. Cell Mol Life Sci. ;
4. Wang W., et al. (2009) Determination of disulfide bridges of two spider toxins: Hainantoxin-III and Hainantoxin-IV. J Venom Anim Toxins incl Trop Dis. ;
5. Xiao Y, et al. (2003) Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol.
Links
| Product code | L8432-100UG |
| Product name | HAINANTOXIN-IV |
| External Links |
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