L8431-100UG - HAINANTOXIN-III
(Syn. : Mu-theraphotoxin-Hhn2a, mu-TRTX-Hhn2a, Peptide F7-18.76, HnTx-III)
(Syn. : Mu-theraphotoxin-Hhn2a, mu-TRTX-Hhn2a, Peptide F7-18.76, HnTx-III)
HAINANTOXIN-III | Product ID | L8431-100UG |
| Name | HAINANTOXIN-III |
| Molecular formula | C154H228N44O45S6 |
| Description |
A 33 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese black earth tiger spider Haplopelma hainanus, also known as Cyriopagopus hainanus. |
| Biological activity | Hainantoxin-III is a sSelective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC50=1270 nM on Nav1.1/SCN1A, 270 nM on Nav1.2/SCN2A, 491 nM on Nav1.3/SCN3A and 232 nM on Nav1.7/SCN9A). It also suppresses Nav1.7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics. It has no activity on Nav1.4, Nav1.5, Nav1.8 and Nav1.9 sodium and calcium currents. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 120.00 | ||
| 5 Unité(s) | 480.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8431-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8431-100UG | Molecular weight | 3608.20 Da |
| Product name | HAINANTOXIN-III | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | D2Y1Y1 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8431-100UG |
| Product name | HAINANTOXIN-III |
- 1. Liu Z., et al. (2013) Structure and Function of Hainantoxin-III, a Selective Antagonist of Neuronal Tetrodotoxin-sensitive Voltage-gated Sodium Channels Isolated from the Chinese Bird Spider Ornithoctonus hainana. JBC. ;
2. Wang W, et al. (2009) Determination of disulfide bridges of two spider toxins: Hainantoxin-III and Hainantoxin-IV. J. Venom. Anim.  Toxins incl. Trop. Dis ;
3. Xiao Y, et al. (2003) Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol.
Links
| Product code | L8431-100UG |
| Product name | HAINANTOXIN-III |
| External Links |
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