L8428-100UG - GrTx1
(Syn. : beta-theraphotoxin-Gr1a, beta-TRTX-Gr1a)
(Syn. : beta-theraphotoxin-Gr1a, beta-TRTX-Gr1a)
GrTx1 | Product ID | L8428-100UG |
| Name | GrTx1 |
| Molecular formula | C159H243N45O41S8 |
| Description |
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chilean rose tarantula Grammostola rosea, also known as Grammostola spatulata. |
| Biological activity | GrTx1 potently and selectively blocks tetrodotoxin-sensivite channels. IC50 values for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 have respectively been described to be of 0.63 nM, 0.23 nM, 0.77 nM, 1.29 nM, 0.63 nM and 0.37 nM. GrTx1 does not inhibit sodium channels Nav1.5/SCN5A (IC50=22 µM) and potassium channels Kv11.2/KCNH6, Kv11.3/KCNH7, Kv1.1/KCNA1 and Kv1.4/KCNA4 (IC50>200 µM). |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 200.00 | ||
| 5 Unité(s) | 800.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8428-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8428-100UG | Molecular weight | 3697.49 Da |
| Product name | GrTx1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P85117 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8428-100UG |
| Product name | GrTx1 |
- 1. Clement H, et al. (2007) Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels ;
2. Redaelli E., et al. (2010) Target Promiscuity and Heterogeneous Effects of Tarantula Venom Peptides Affecting Na and K Ion Channels.
Links
| Product code | L8428-100UG |
| Product name | GrTx1 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
