(Syn. : GxTx-1E, kappa-theraphotoxin-Pg1a, kappa-TRTX-Pg1a)
GUANGXITOXIN-1E | Product ID | L8426-100UG |
| Name | GUANGXITOXIN-1E |
| Molecular formula | C178H248N44O45S7 |
| Description |
A 36 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Chinese fawn tarantula Plesiophrictus guangxiensi, also known as Chilobrachys jingzhao. |
| Biological activity | Guangxitoxin-1E (GxTx-1E) is a gating modifier of Kv2.1/KCNB1 (IC50=5.1 nM), Kv2.2/KCNB2 and Kv4.3/KCND3 channels (IC50=39 nM). Acts by shifting the channel activation to more depolarized potentials by stabilizing the resting conformation of the voltage sensor. It completely inhibits opening of the Kv2.1/KCNB1 channel at negative membrane voltages and dramatically shifts channel activation to positive voltages. May act by partitioning into lipid membranes and then by binding the voltage sensor paddle of the channel from a place within the membrane. It has no significant effects on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 140.00 | ||
| 5 Unité(s) | 560.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8426-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8426-100UG | Molecular weight | 3948.70 Da |
| Product name | GUANGXITOXIN-1E | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P84835 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513878 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8426-100UG |
| Product name | GUANGXITOXIN-1E |
- 1. Herrington J., (2009) Gating modifier peptides as probes of pancreatic beta-cell physiology. Toxicon.  ;
2. Herrington J., et al. (2006) Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. ;
3. Li XN., et al. (2013) The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J Pharmacol Exp Ther. ;
4. Palacio S., et al. (2017) Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro. PMCID: PMC5569380. DOI: 10.1523/ENEURO.0267-17.2017. ;
5. Ratliff KS., et al. (2008) An automated electrophysiology serum shift assay for K(V) channels. Assay Drug Dev Technol. ;
6. Yoshida M., et al. (2009) Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic beta-cells. FEBS Lett.  ;
7. Zhuang GQ., et al. (2009) SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells. Biochem Biophys Res Commun.
Links
| Product code | L8426-100UG |
| Product name | GUANGXITOXIN-1E |
| External Links |
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