L8424-100UG - PUROTOXIN-1
(Syn. : PT-1)
(Syn. : PT-1)
PUROTOXIN-1 | Product ID | L8424-100UG |
| Name | PUROTOXIN-1 |
| Molecular formula | C155H248N50O48S8 |
| Description |
A 35 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of a species of burrowing wolf spider from Central Asia, Geolycosa sp. |
| Biological activity | Purotoxin-1 (PT-1) inhibits selectively P2X3 receptor channels at a 100 nM concentration, making it the most potent and selective ligand for P2X3. Studies did not show any inhibitory effect of PT-1 on voltage-gated channels (potentials range tested from -100 to 20 mV), neither on TRPV1 (after activation with 500 nM capsaicin). Therapeutic interest : pain, as P2X3 receptors are known to be implicated in pain mechanisms. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 150.00 | ||
| 5 Unité(s) | 600.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8424-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8424-100UG | Molecular weight | 3834.59 Da |
| Product name | PUROTOXIN-1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P86269 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90488991 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8424-100UG |
| Product name | PUROTOXIN-1 |
- 1. E.V. Grishin, et al. (2010) Novel peptide from spider venom inhibits P2X3 receptors and inflammatory pain. ANN NEUROL. ;
2. G. A. Savchenko, et al. (2010) Purinergic Membrane Receptors as Targets for the Effect of Purotoxin 1, a Component of Venom of Spiders from the Geolycosa Genus. Neurophysiology. ;
3. Kabanova NV, et al. (2012) Modulation of P2X3 receptors by spider toxins. Biochim Biophys Acta.
Links
| Product code | L8424-100UG |
| Product name | PUROTOXIN-1 |
| External Links |
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Toxicology Citations From PubMed
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