L8234-100UG - TOXIN OD1 (alpha-)
(Syn. : Alpha-toxin OD1)
(Syn. : Alpha-toxin OD1)
TOXIN OD1 (alpha-) | Product ID | L8234-100UG |
| Name | TOXIN OD1 (alpha-) |
| Molecular formula | C308H466N90O95S8 |
| Description |
A 65 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Yellow Iranian scorpion Odontobuthus doriae. |
| Biological activity | Alpha-toxin OD1 affects mammalian sodium channels Nav1.7/SCN9A (EC(50)=4.5 nM), Nav1.4/SCN4A (EC(50)=9.6 nM), Nav1.6/SCN8A (EC(50)=30 nM), Nav1.5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM). In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw, this is used as a pharmacological tool to establish a Nav1.7/SCN9A-mediated mouse model of pain. Mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 270.00 | ||
| 5 Unité(s) | 1 080.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8234-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8234-100UG | Molecular weight | 7206.20 Da |
| Product name | TOXIN OD1 (alpha-) | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P84646 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513905 | ||
| Purity | > 95 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | Use gloves, wear mask and manipulate under hood. |
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Bibliographic References
| Product code | L8234-100UG |
| Product name | TOXIN OD1 (alpha-) |
- 1. Durek T., et al. (2013) Chemical Engineering and Structural and Pharmacological Characterization of the Scorpion Toxin OD1. ACS. PIMD: 3527544 ;
- 2. Jalali A., et al. (2005) OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels. FEBS. ;
- 3. Maertens C., et al. (2006) Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae. Mol. Pharmacol.
Links
| Product code | L8234-100UG |
| Product name | TOXIN OD1 (alpha-) |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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