L8233-100UG - LEIUROPEPTIDE II
(Syn. : GaTx2, Potassium channel toxin alpha-KTx 8.3, lpII)
(Syn. : GaTx2, Potassium channel toxin alpha-KTx 8.3, lpII)
LEIUROPEPTIDE II | Product ID | L8233-100UG |
| Name | LEIUROPEPTIDE II |
| Molecular formula | C125H199N39O47S6 |
| Description |
A 29 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Palestine yellow scorpion Leiurus quinquestriatus hebraeus. |
| Biological activity | A specific and potent inhibitor of ClC-2/CLCN2 chloride channel. It slows ClC-2/CLCN2 activation by increasing the latency to first opening by nearly 8-fold but is unable to inhibit open channels, suggesting that this toxin inhibits channel activation gating. GaTx2 does not inhibit ClC-0, ClC-1/CLCN1, ClC-3/CLCN3, ClC-4/CLCN4, CFTR chloride channel, GABRR, calcium-activated chloride channel regulator (Cl(Ca)), Shaker, and Kv1.2/KCNA2. It shows sequence similarities with potassium channel inhibitors, but inhibits chloride channels. It is why the systematic name 'Potassium channel toxin alpha-KTx 8.3' has been moved as alternative name. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 190.00 | ||
| 5 Unité(s) | 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8233-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8233-100UG | Molecular weight | 3191.25 Da |
| Product name | LEIUROPEPTIDE II | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P80670 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 131954575 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8233-100UG |
| Product name | LEIUROPEPTIDE II |
- 1. Eric E, et al. (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol. ;
2. Thompson CH, et al. (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J Biol Chem.
Links
| Product code | L8233-100UG |
| Product name | LEIUROPEPTIDE II |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
