L8232-100UG - AGITOXIN-2
(Syn. : AgTx-2, Potassium channel toxin alpha-KTx 3.2)
(Syn. : AgTx-2, Potassium channel toxin alpha-KTx 3.2)
AGITOXIN-2 | Product ID | L8232-100UG |
| Name | AGITOXIN-2 |
| Molecular formula | C169H278N54O48S8 |
| Description |
A 38 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Palestine yellow scorpion Leiurus quinquestriatus hebraeus. |
| Biological activity | A potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels). AgTx also blocks Kv1.2/KCNA2 (IC50=26.8 nM). It shows weak blocking activity on KCa3.1/KCNN4 (IC50=1152 nM). |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8232-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8232-100UG | Molecular weight | 4090.89 Da |
| Product name | AGITOXIN-2 | Physical form | White lyophilized solid |
| CAS No. | 168147-41-9 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P46111 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 90489022 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8232-100UG |
| Product name | AGITOXIN-2 |
- 1. Anangi R., et al. (2012) Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for production of KV1.3 Channel Blockers. PLoS ONE. ;
2. Garcia, M.L. et al. (1994) Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry.
Links
| Product code | L8232-100UG |
| Product name | AGITOXIN-2 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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PubChem CID
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 UNIPROT |
