L8231-100UG - HsTx1
(Syn. : Potassium channel toxin alpha-KTx 6.3, Neurotoxin HsTX1)
(Syn. : Potassium channel toxin alpha-KTx 6.3, Neurotoxin HsTX1)
HsTx1 | Product ID | L8231-100UG |
| Name | HsTx1 |
| Molecular formula | C149H246N54O46S9 |
| Description |
A 34 amino-acids peptide with 4 disulfide bridges , synthetic, initially isolated from the venom of the Giant forest scorpion Heterometrus spinifer. |
| Biological activity | HsTx-1 potently blocks voltage-gated Kv1.3 channels (Kd close to 10 pM). HsTx-1 is also very active on Kv1.1 channels (IC50 around 7 nM). It is one of the most potent toxins active on Kv1.3 channel. HsTx-1 does not block Kv1.2/KCNA2 potassium channels and is inactive on apamin-sensitive SK channels. |
Packaging and Prices

| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 190.00 | ||
| 5 Unité(s) | 760.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8231-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8231-100UG | Molecular weight | 3819.87 Da |
| Product name | HsTx1 | Physical form | White lyophilized solid |
| CAS No. | NA | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | P59867 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | NA | ||
| Purity | > 99 % (HPLC, MALDI TOF) | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8231-100UG |
| Product name | HsTx1 |
- 1. Lebrun, B., et al. (1997) A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrusspinnifer (Scorpionidae) venom. Biochem. ;
2. Rashid MH, et al. (2014) A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases. Sci Rep. ;
3. Savarin, P., et al. (1999) Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1. Protein Sci.
Links
| Product code | L8231-100UG |
| Product name | HsTx1 |
| External Links |
PubMed
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Biomedical Citations From PubMed
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Toxicology Citations From PubMed
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