(Syn. : Neurotoxin BeKm-1, Potassium channel toxin gamma-KTx 2.1)
BeKm1 | Product ID | L8227-100UG |
| Name | BeKm1 |
| Molecular formula | C174H261N51O52S6 |
| Description |
A 36 amino-acids peptide with 3 disulfide bridges , synthetic, initially isolated from the venom of the Lesser Asian scorpion Buthus eupeus. |
| Biological activity | BeKm-1 toxin, a potassium channel toxin gamma-KTx 2.1, blocks human and/or rat Kv11.1/KCNH2/ERG1, Kv11.2/KCNH6/ERG2 and Kv11.3/KCNH7/ERG3 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry. Reported Kd and IC50 are: hERG1 (reversible, Kd=7.7 nM), IC50=3.3 nM, IC50=11.9 nM, rERG1 (reversible, Kd=19 nM), hERG2 (reversible, Kd=77 nM), rERG2 (irreversible, Kd=4.2 nM, hERG3 (reversible, Kd=11.5 nM) and rERG3 (reversible, Kd=747 nM) potassium channels. BeKm-1 toxin (at 100 nM) does not inhibit hEAG1/KCNH1, hBK/KCa1.1/KCNMA1, hSK1/KCa2.1/KCNN1, rSK2/KCa2.2/KCNN2, hIK/KCa3.1/KCNN4, KCNQ1+KCNE1, KCNQ2+KCNQ3 and KCNQ4 channels. At 50 nM it does not either inhibit Kv1.2/KCNA2, Kv1.4/KCNA4, Kv2.1/KCNB1, Kv4.3/KCND3, Kir1.1/KCNJ1. |
Packaging and Prices
| Packaging | Price (€) | Quantité | Buy Now |
|---|---|---|---|
| 1 Unité(s) | 130.00 | ||
| 5 Unité(s) | 520.00 | ||
| For quotation of big quantities, please Contact us | |||
Product Technical Documents
 | Safety Data Sheet Available on request, please Contact us Ref. SDS_L8227-100UG : unit price : free of charge |
Chemical and Physical Properties
| Product code | L8227-100UG | Molecular weight | 4091.70 Da |
| Product name | BeKm1 | Physical form | White lyophilized solid |
| CAS No. | 524962-01-4 | Melting point | |
| RTECS | NA | Solubility | water and saline buffer |
| UNIPROT | Q9BKB7 | Optical Activity | |
| PubChem SID | |||
| PubChem CID | 121513903 | ||
| Purity | > 98 % | ||
| Toxicity(LD50) | No Data | ||
| Chemical Name | |||
| Storage & Reconstitution Recommandations |
Stable at room temperature, store preferably at 4°C |
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| Savety Recommandations | |||
Bibliographic References
| Product code | L8227-100UG |
| Product name | BeKm1 |
- 1. Korolkova Y., et al. (2001) An ERG Channel Inhibitor from the Scorpion Buthus eupeus. JBC. ;
2. Korolkova Y., et al. (2002) New Binding Site on Common Molecular Scaffold Provides HERG Channel Specificity of Scorpion Toxin BeKm-1. JBC. ;
3. Milnes J., et al. (2003) Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Letters. PMID12860380 ;
4. Qu Y., et al. (2011) BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. J Pharmacol Exp Ther. PMID 21205913 ;
5. Yi H., et al. (2007) Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide: insights into the selectivity of molecular recognition. J Proteome Res. PMID 17269718
Links
| Product code | L8227-100UG |
| Product name | BeKm1 |
| External Links |
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